{"id":1297,"date":"2024-07-31T14:29:43","date_gmt":"2024-07-31T14:29:43","guid":{"rendered":"https:\/\/gimm.pt\/our-work\/laboratories\/laboratorio-paula-duque\/"},"modified":"2026-01-29T16:42:30","modified_gmt":"2026-01-29T16:42:30","slug":"laboratorio-paula-duque","status":"publish","type":"lab","link":"https:\/\/gimm.pt\/pt-pt\/o-nosso-trabalho\/laboratorios\/laboratorio-paula-duque\/","title":{"rendered":"Laborat\u00f3rio Paula Duque"},"content":{"rendered":"\n

Biologia Molecular Vegetal<\/h3>\n\n\n\n

<\/p>\n\n\n\n

Como organismos s\u00e9sseis, as plantas desenvolveram estrat\u00e9gias \u00fanicas para lidar com os desafios ambientais que afectam o seu crescimento e desenvolvimento. Estas v\u00e3o desde as altera\u00e7\u00f5es morfol\u00f3gicas e fisiol\u00f3gicas at\u00e9 \u00e0s altera\u00e7\u00f5es a n\u00edvel celular, mas a base da adapta\u00e7\u00e3o ou aclimata\u00e7\u00e3o encontra-se, em \u00faltima an\u00e1lise, a n\u00edvel do genoma.<\/p>\n\n\n\n

O grupo de Biologia Molecular de Plantas Arabidopsis thaliana<\/em> como um sistema modelo para investigar como as plantas percebem e respondem ao stress ambiental a n\u00edvel molecular. Em particular, estamos a centrar-nos no papel do splicing alternativo do RNA na regula\u00e7\u00e3o da express\u00e3o gen\u00e9tica. A versatilidade deste mecanismo de regula\u00e7\u00e3o p\u00f3s-transcricional sugere uma contribui\u00e7\u00e3o importante para assegurar a plasticidade do desenvolvimento e a toler\u00e2ncia ao stress essencial para a sobreviv\u00eancia das plantas.<\/p>\n\n\n\n

Outro grande projeto do laborat\u00f3rio \u00e9 a descoberta de um papel para os transportadores de membrana da Superfam\u00edlia de Facilitadores Principais (MFS) no desenvolvimento das plantas e nas respostas ao stress abi\u00f3tico. Curiosamente, a an\u00e1lise funcional destas prote\u00ednas de membrana est\u00e1 a revelar exemplos impressionantes do impacto biol\u00f3gico do splicing alternativo nas plantas.<\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"
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