{"id":1308,"date":"2024-07-31T14:29:45","date_gmt":"2024-07-31T14:29:45","guid":{"rendered":"https:\/\/gimm.pt\/our-work\/laboratories\/laboratorio-nuno-santos\/"},"modified":"2026-05-27T15:26:08","modified_gmt":"2026-05-27T15:26:08","slug":"laboratorio-nuno-santos","status":"publish","type":"lab","link":"https:\/\/gimm.pt\/pt-pt\/o-nosso-trabalho\/laboratorios\/laboratorio-nuno-santos\/","title":{"rendered":"Laborat\u00f3rio Nuno Santos"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Biomembranas e nanomedicina<\/h3>\n\n\n\n<p>Processos bioqu\u00edmicos e biof\u00edsicos que ocorrem ao n\u00edvel das membranas das c\u00e9lulas humanas, bem como dos seus agentes patog\u00e9nicos virais e bacterianos. Estudo das duas etapas do ciclo de vida dos v\u00edrus envelopados (principalmente HIV-1 e v\u00edrus da dengue) que envolvem biomembranas &#8211; a entrada do v\u00edrus ou do seu conte\u00fado na c\u00e9lula-alvo e a forma\u00e7\u00e3o de novos viri\u00f5es. Estudo da liga\u00e7\u00e3o do fibrinog\u00e9nio \u00e0 membrana eritrocit\u00e1ria e da sua import\u00e2ncia como fator de risco cardiovascular.<\/p>\n\n\n\n<p>Avalia\u00e7\u00e3o pr\u00e9-cl\u00ednica da atividade membranar e do mecanismo de a\u00e7\u00e3o a n\u00edvel molecular dos p\u00e9ptidos antimicrobianos (AMP) e dos p\u00e9ptidos de penetra\u00e7\u00e3o celular (CPP). Na \u00e1rea da Nanotecnologia\/Nanomedicina, estamos tamb\u00e9m a trabalhar no desenvolvimento de sistemas inovadores de biossensores, com maior seletividade e sensibilidade (por exemplo, nanopart\u00edculas e biossensores baseados em amiloide).<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div style=\"position: relative;\" id=\"\" class=\"alignfull\">\n\n\t\n\t\n\t<div style=\"background-color: unset;\" class=\"wrapper_section divider  \">\n\n\t\t<section >\n\t\t\t<div class=\"container\">\n\n\n\t\t\t\t\t\t\t\t<div class=\"acf-innerblocks-container\">\n<div id=\"\" class=\"wp-block-gimm-accordion\">\n\n\t<div class=\"accordion\" id=\"accordion\">\n\t\t\t\t\t\t<div class=\"accordion-item\">\n\t\t\t\t\t<h2 class=\"accordion-header\" id=\"header-areas-de-investigacao\">\n\t\t\t\t\t\t<button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n\t\t\t\t\t\t\tdata-bs-target=\"#areas-de-investigacao\"\n\t\t\t\t\t\t\taria-expanded=\"false\" aria-controls=\"areas-de-investigacao\">\n\t\t\t\t\t\t\t<h3>\u00c1reas de Investiga\u00e7\u00e3o<\/h3>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\t<div id=\"areas-de-investigacao\" class=\"accordion-collapse collapse\"\n\t\t\t\t\t\tdata-bs-parent=\"#accordion\">\n\t\t\t\t\t\t<div class=\"accordion-body\">\n\t\t\t\t\t\t\t<ul>\n<li style=\"font-weight: 400\">Biof\u00edsica<\/li>\n<li style=\"font-weight: 400\">Nanomedicina<\/li>\n<li style=\"font-weight: 400\">Biossensores<\/li>\n<li style=\"font-weight: 400\">Biologia sint\u00e9tica<\/li>\n<li style=\"font-weight: 400\">Avalia\u00e7\u00e3o do risco cardiovascular<\/li>\n<li style=\"font-weight: 400\">V\u00edrus envelopados<\/li>\n<li style=\"font-weight: 400\">Revestimentos de superf\u00edcies antimicrobianos<\/li>\n<li style=\"font-weight: 400\">P\u00e9ptidos antimicrobianos<\/li>\n<li style=\"font-weight: 400\">P\u00e9ptidos anticancer\u00edgenos<\/li>\n<li style=\"font-weight: 400\">Envelhecimento da membrana nuclear<\/li>\n<li style=\"font-weight: 400\">Microscopia de for\u00e7a at\u00f3mica<\/li>\n<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"accordion-item\">\n\t\t\t\t\t<h2 class=\"accordion-header\" id=\"header-projetos\">\n\t\t\t\t\t\t<button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n\t\t\t\t\t\t\tdata-bs-target=\"#projetos\"\n\t\t\t\t\t\t\taria-expanded=\"false\" aria-controls=\"projetos\">\n\t\t\t\t\t\t\t<h3>Projetos<\/h3>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\t<div id=\"projetos\" class=\"accordion-collapse collapse\"\n\t\t\t\t\t\tdata-bs-parent=\"#accordion\">\n\t\t\t\t\t\t<div class=\"accordion-body\">\n\t\t\t\t\t\t\t<p><strong>2025\/2028:<\/strong> <a href=\"https:\/\/gimm.pt\/wp-content\/uploads\/2026\/05\/BIODyes_ficha-de-operacao3aversao_final.pdf\" target=\"_blank\" rel=\"noopener\">BIODyes &#8211; Desenvolvimento de Biopigmentos para Tingimento e Estampagem Sustent\u00e1veis<\/a>. Participa\u00e7\u00e3o: Nuno Santos. Ag\u00eancia Financiadora: Compete 2030, Lisboa 2030, Portugal 2030 e Uni\u00e3o Europeia.<\/p>\n<p style=\"font-weight: 400\"><strong>2025\/2028:<\/strong> Nano2FILM &#8211; Targeted multiplexed lipid nanocarriers against drug-resistant bacterial biofilm. Participa\u00e7\u00e3o: Nuno Santos. Ag\u00eancia Financiadora: Uni\u00e3o Europeia (ERA4Health Joint Transnational Call for Proposals 2024 \u201cNano and advanced technologies for disease prevention, diagnostic and therapy\u201d (NANOTECMEC)).<\/p>\n<p style=\"font-weight: 400\"><strong>2025\/2026:<\/strong> NucLeAR &#8211; Age-defying nucleus: targeting plasmalogens to reverse age-induced biomechanical decline. Coordena\u00e7\u00e3o: Maria Jo\u00e3o Sarmento. Ag\u00eancia Financiadora: Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia.<\/p>\n<p style=\"font-weight: 400\"><strong>2025\/2026:<\/strong> SMART-DIET &#8211; Developing next-generation tools for surveillance and control of Aedes albopictus, a major vector of dengue and Zika viruses. Coordena\u00e7\u00e3o: Gon\u00e7alo Seixas. Ag\u00eancia Financiadora: Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia.<\/p>\n<p style=\"font-weight: 400\"><strong>2024\/2026:<\/strong> SynEry &#8211; Bottom-up reconstruction of a Synthetic Erythrocyte: biophysical properties, biomechanical assessment and cell-cell interactions. Coordena\u00e7\u00e3o: Nuno Santos. Ag\u00eancia Financiadora: Uni\u00e3o Europeia (HORIZON-EIC-2021-PATHFINDEROPEN-01; Project number: 101046894).<\/p>\n<p style=\"font-weight: 400\"><strong>2023\/2025:<\/strong> Res4PrioPath \u2013 An Integrated Antiviral Discovery Platform of Broad-Spectrum Small Molecule Inhibitors of Viral Targets from Priority Preparedness Pathogens. Coordena\u00e7\u00e3o: Nuno Santos. Ag\u00eancia Financiadora: Uni\u00e3o Europeia (ISIDORe JRA Programme).<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"accordion-item\">\n\t\t\t\t\t<h2 class=\"accordion-header\" id=\"header-projetos-anteriores\">\n\t\t\t\t\t\t<button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n\t\t\t\t\t\t\tdata-bs-target=\"#projetos-anteriores\"\n\t\t\t\t\t\t\taria-expanded=\"false\" aria-controls=\"projetos-anteriores\">\n\t\t\t\t\t\t\t<h3>Projetos Anteriores<\/h3>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\t<div id=\"projetos-anteriores\" class=\"accordion-collapse collapse\"\n\t\t\t\t\t\tdata-bs-parent=\"#accordion\">\n\t\t\t\t\t\t<div class=\"accordion-body\">\n\t\t\t\t\t\t\t<p style=\"font-weight: 400\"><strong>2023\/2024:<\/strong> AMP-AgNP conjugates: the mutual reinforcement of antibacterial activity. Coordena\u00e7\u00e3o: S\u00f3nia Gon\u00e7alves. Ag\u00eancia Financiadora: Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia.<\/p>\n<p style=\"font-weight: 400\"><strong>2023\/2024:<\/strong> Biophysical studies of flavivirus capsid protein interactions with key biological targets to achieve its future inhibition. Coordena\u00e7\u00e3o: Ivo Martins. Ag\u00eancia Financiadora: Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia.<\/p>\n<p style=\"font-weight: 400\"><strong>2023\/2024:<\/strong> ImPlat: A single-cell platform to validate material scaffolds and drugs for the enhanced osteointegration of biomedical implants. Coordena\u00e7\u00e3o: Nuno Santos. Ag\u00eancia Financiadora: PRR (Call for Proposals: Human-Based Models as Drug Discovery Tools).<\/p>\n<p style=\"font-weight: 400\"><strong>2022\/2024:<\/strong> COMPLICE: COoperative Mechanical couPling of adherens junctions and focal adhesIons supporting breast CancEr progression. Coordena\u00e7\u00e3o: Nuno Santos. Ag\u00eancia Financiadora: Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia.<\/p>\n<p style=\"font-weight: 400\"><strong>2022\/2024:<\/strong> Nano-coatings for prosthetics based on microbial phenazines conjugated with silver nanostars. Coordena\u00e7\u00e3o: Pedro Castro. Ag\u00eancia Financiadora: Funda\u00e7\u00e3o \u201cla Caixa\u201d.<\/p>\n<p style=\"font-weight: 400\"><strong>2021\/2024:<\/strong> Fibrinogen-erythrocyte interaction as a new approach on the early detection of thrombotic events in vascular diseases. Coordena\u00e7\u00e3o: Nuno Santos. Ag\u00eancia Financiadora: Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"accordion-item\">\n\t\t\t\t\t<h2 class=\"accordion-header\" id=\"header-publicacoes-seleccionadas\">\n\t\t\t\t\t\t<button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n\t\t\t\t\t\t\tdata-bs-target=\"#publicacoes-seleccionadas\"\n\t\t\t\t\t\t\taria-expanded=\"false\" aria-controls=\"publicacoes-seleccionadas\">\n\t\t\t\t\t\t\t<h3>Publica\u00e7\u00f5es Seleccionadas<\/h3>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\t<div id=\"publicacoes-seleccionadas\" class=\"accordion-collapse collapse\"\n\t\t\t\t\t\tdata-bs-parent=\"#accordion\">\n\t\t\t\t\t\t<div class=\"accordion-body\">\n\t\t\t\t\t\t\t<p data-start=\"50\" data-end=\"301\">A.F. Guedes, F.A. Carvalho, I. Malho, N. Lousada, L. Sargento, N.C. Santos (2016). Atomic force microscopy as a tool to evaluate the risk of cardiovascular diseases in patients. <em data-start=\"228\" data-end=\"251\">Nature Nanotechnology<\/em> 11: 687. <a target=\"_new\" rel=\"noopener\" data-start=\"261\" data-end=\"298\">https:\/\/doi.org\/10.1038\/nnano.2016.52<\/a>.<\/p>\n<p data-start=\"303\" data-end=\"577\">A.F. Guedes, F.A. Carvalho, C. Moreira, J.B. Nogueira, N.C. Santos (2017). Essential arterial hypertension patients present higher cell adhesion forces, contributing to fibrinogen-dependent cardiovascular risk. <em data-start=\"514\" data-end=\"525\">Nanoscale<\/em> 9(39): 14897. <a target=\"_new\" rel=\"noopener\" data-start=\"540\" data-end=\"574\">https:\/\/doi.org\/10.1039\/C7NR03891G<\/a>.<\/p>\n<p data-start=\"579\" data-end=\"840\">A.F. Guedes, C. Moreira, J.B. Nogueira, N.C. Santos, F.A. Carvalho (2019). Fibrinogen-erythrocyte binding and hemorheology measurements in the assessment of essential arterial hypertension patients. <em data-start=\"778\" data-end=\"789\">Nanoscale<\/em> 11(6): 2757. <a target=\"_new\" rel=\"noopener\" data-start=\"803\" data-end=\"837\">https:\/\/doi.org\/10.1039\/C8NR04398A<\/a>.<\/p>\n<p data-start=\"842\" data-end=\"1142\">P.M. Silva, I.V. da Silva, M.J. Sarmento, \u00cd.C. Silva, F.A. Carvalho, G. Soveral, N.C. Santos (2022). Aquaporin-3 and Aquaporin-5 facilitate migration and cell-cell adhesion in pancreatic cancer by modulating cell biomechanical properties. <em data-start=\"1081\" data-end=\"1088\">Cells<\/em> 11(8): 1308. <a target=\"_new\" rel=\"noopener\" data-start=\"1102\" data-end=\"1139\">https:\/\/doi.org\/10.3390\/cells11081308<\/a>.<\/p>\n<p data-start=\"1144\" data-end=\"1525\">A.L. Tom\u00e1s, A. Reichel, P.M. Silva, P.G. Silva, J. Pinto, I. Calado, J. Campos, I. Silva, V. Machado, R. Laranjeira, P. Abreu, P. Mendes, N.B. Sedrine, N.C. Santos (2022). UV-C irradiation-based inactivation of SARS-CoV-2 in contaminated porous and non-porous surfaces. <em data-start=\"1414\" data-end=\"1460\">Journal of Photochemistry and Photobiology B<\/em> 234: 112531. <a target=\"_new\" rel=\"noopener\" data-start=\"1474\" data-end=\"1522\">https:\/\/doi.org\/10.1016\/j.jphotobiol.2022.112531<\/a>.<\/p>\n<p data-start=\"1527\" data-end=\"1725\">M.M. Domingues, F.A. Carvalho, N.C. Santos (2022). Nanomechanics of blood clot and thrombus formation. <em data-start=\"1630\" data-end=\"1659\">Annual Review of Biophysics<\/em> 51: 201. <a target=\"_new\" rel=\"noopener\" data-start=\"1669\" data-end=\"1722\">https:\/\/doi.org\/10.1146\/annurev-biophys-111821-072110<\/a>.<\/p>\n<p data-start=\"1727\" data-end=\"1963\">M.C. Marques, D. Lousa, P.M. Silva, A.F. Faustino, C.M. Soares, N.C. Santos (2022). The importance of lipid conjugation on anti-fusion peptides against Nipah virus. <em data-start=\"1892\" data-end=\"1906\">Biomedicines<\/em> 10: 703. <a target=\"_new\" rel=\"noopener\" data-start=\"1916\" data-end=\"1960\">https:\/\/doi.org\/10.3390\/biomedicines10030703<\/a>.<\/p>\n<p data-start=\"1965\" data-end=\"2275\">M. Makowski, V.G. Almendro-Vedia, M.M. Domingues, O.L. Franco, I. L\u00f3pez-Montero, M.N. Melo, N.C. Santos (2023). Activity modulation of the <em data-start=\"2104\" data-end=\"2122\">Escherichia coli<\/em> F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering. <em data-start=\"2207\" data-end=\"2217\">iScience<\/em> 26: 107004. <a target=\"_new\" rel=\"noopener\" data-start=\"2230\" data-end=\"2272\">https:\/\/doi.org\/10.1016\/j.isci.2023.107004<\/a>.<\/p>\n<p data-start=\"2277\" data-end=\"2543\">C.S. Lopes, J. Curty, F.A. Carvalho, A. Hern\u00e1ndez-Machado, K. Kinoshita, N.C. Santos, R.D.M. Travasso (2023). A mathematical model of fibrinogen-mediated erythrocyte-erythrocyte adhesion. <em data-start=\"2465\" data-end=\"2489\">Communications Biology<\/em> 6: 192. <a target=\"_new\" rel=\"noopener\" data-start=\"2498\" data-end=\"2540\">https:\/\/doi.org\/10.1038\/s42003-023-04560-4<\/a>.<\/p>\n<p data-start=\"2545\" data-end=\"2839\">A.S. Martins, F.A. Carvalho, A.R. Nascimento, N.M. Silva, T.V. Rebelo, A.F. Faustino, F.J. Enguita, R.G. Huber, N.C. Santos, I.C. Martins (2024). Zika virus capsid protein closed structure modulates binding to host lipid systems. <em data-start=\"2775\" data-end=\"2792\">Protein Science<\/em> 33: e5142. <a target=\"_new\" rel=\"noopener\" data-start=\"2804\" data-end=\"2836\">https:\/\/doi.org\/10.1002\/pro.5142<\/a>.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"accordion-item\">\n\t\t\t\t\t<h2 class=\"accordion-header\" id=\"header-premios\">\n\t\t\t\t\t\t<button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n\t\t\t\t\t\t\tdata-bs-target=\"#premios\"\n\t\t\t\t\t\t\taria-expanded=\"false\" aria-controls=\"premios\">\n\t\t\t\t\t\t\t<h3>Pr\u00e9mios<\/h3>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h2>\n\t\t\t\t\t<div id=\"premios\" class=\"accordion-collapse collapse\"\n\t\t\t\t\t\tdata-bs-parent=\"#accordion\">\n\t\t\t\t\t\t<div class=\"accordion-body\">\n\t\t\t\t\t\t\t<p style=\"font-weight: 400\"><strong>2023:<\/strong> ULisboa \/ Caixa Geral de Dep\u00f3sitos Prize (Biology, Biological Engineering, Biochemistry and Biotechnology).<\/p>\n<p style=\"font-weight: 400\"><strong>2017: <\/strong>ULisboa \/ Caixa Geral de Dep\u00f3sitos Prize (Biology, Biological Engineering, Biochemistry and Biotechnology).<\/p>\n<p style=\"font-weight: 400\"><strong>2005:<\/strong> Dr. Jos\u00e9 Lu\u00eds Champalimaud Prize on HIV Research (Applied Research and Technologies area).<\/p>\n<p style=\"font-weight: 400\"><strong>2004: <\/strong>Dr. Jos\u00e9 Lu\u00eds Champalimaud Prize on HIV Research (Basic Research area).<\/p>\n<p style=\"font-weight: 400\"><strong>2001:<\/strong> Calouste Gulbenkian Foundation Prize in Biophysics.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\n<\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/section>\n\t<\/div>\n\n<\/div>","protected":false},"featured_media":0,"template":"","acf":{"header_image":false,"ongoing_projects":"","selected_publications":"","useful_links":"","awards":"","funding":"","sponsorship":"","extra_information":false,"location":"Lisboa","subtitle":"Biomembranas e nanomedicina","team_leader":[{"ID":8308,"post_author":"1004","post_date":"2025-05-27 13:42:56","post_date_gmt":"2025-05-27 13:42:56","post_content":"","post_title":"Nuno Santos","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nuno-fernando-duarte-cordeiro-correia-dos-santos","to_ping":"","pinged":"","post_modified":"2026-03-13 10:02:46","post_modified_gmt":"2026-03-13 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