<\/p>\n\n
O principal foco de investiga\u00e7\u00e3o do nosso laborat\u00f3rio \u00e9 o estudo da reconstitui\u00e7\u00e3o imunit\u00e1ria ap\u00f3s o transplante de c\u00e9lulas estaminais hematopoi\u00e9ticas (HSCT) em humanos e o desenvolvimento de estrat\u00e9gias que modulem as respostas imunit\u00e1rias e a toler\u00e2ncia p\u00f3s-transplante. A imunidade do dador que surge ap\u00f3s o transplante desempenha um papel fundamental na prote\u00e7\u00e3o contra agentes patog\u00e9nicos, como o Aspergillus, o CMV e o EBV, bem como no desenvolvimento da doen\u00e7a do enxerto contra o hospedeiro (GVHD) e do efeito do enxerto contra a leucemia.<\/p>\n\n
O nosso laborat\u00f3rio tem como objetivo identificar os factores de risco imunol\u00f3gicos e os mecanismos pelos quais estas complica\u00e7\u00f5es surgem no p\u00f3s-transplante. Estamos particularmente interessados no desenvolvimento de estrat\u00e9gias que possam ser transpostas para o contexto cl\u00ednico, como a utiliza\u00e7\u00e3o de c\u00e9lulas T espec\u00edficas de agentes patog\u00e9nicos, c\u00e9lulas T reguladoras do dador para GVHD e c\u00e9lulas T espec\u00edficas da doen\u00e7a, com o objetivo de melhorar a sobreviv\u00eancia dos doentes.<\/p>\n\n
Continuamos a desenvolver v\u00e1rias linhas de investiga\u00e7\u00e3o no dom\u00ednio da suscetibilidade gen\u00e9tica para infec\u00e7\u00f5es virais e f\u00fangicas ap\u00f3s o transplante de c\u00e9lulas estaminais hematopoi\u00e9ticas.<\/p>\n\n
Mais recentemente, empenh\u00e1mo-nos no desenvolvimento de v\u00e1rias estrat\u00e9gias inovadoras para as terapias com c\u00e9lulas T CAR de doen\u00e7as malignas hematol\u00f3gicas e tumores s\u00f3lidos.<\/p>\n","protected":false},"featured_media":0,"template":"","acf":{"header_image":false,"ongoing_projects":"","selected_publications":"","useful_links":"","awards":"","funding":null,"sponsorship":null,"extra_information":false,"location":"Lisboa","subtitle":"Hematologia e Imunologia de Transplantes","team_leader":[],"order":"200","related_research_areas":[1499],"lab_members":[{"ID":8353,"post_author":"1004","post_date":"2025-05-27 13:42:49","post_date_gmt":"2025-05-27 13:42:49","post_content":"","post_title":"Jo\u00e3o Lacerda","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"joao-mascarenhas-forjaz-de-lacerda","to_ping":"","pinged":"","post_modified":"2026-03-13 10:01:47","post_modified_gmt":"2026-03-13 10:01:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/gimm.pt\/people\/joao-mascarenhas-forjaz-de-lacerda\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":7435,"post_author":"1002","post_date":"2025-05-27 13:45:11","post_date_gmt":"2025-05-27 13:45:11","post_content":"","post_title":"Diogo Silva","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"diogo-silva","to_ping":"","pinged":"","post_modified":"2025-05-27 13:45:11","post_modified_gmt":"2025-05-27 13:45:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/gimm.pt\/people\/diogo-silva\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6715,"post_author":"1002","post_date":"2025-05-27 13:47:27","post_date_gmt":"2025-05-27 13:47:27","post_content":"","post_title":"Ana Teresa Da Silva Pais","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ana-teresa-da-silva-pais","to_ping":"","pinged":"","post_modified":"2025-05-27 13:47:27","post_modified_gmt":"2025-05-27 13:47:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/gimm.pt\/people\/ana-teresa-da-silva-pais\/","menu_order":0,"post_type":"people","post_mime_type":"","comment_count":"0","filter":"raw"}],"list_image":{"ID":10853,"id":10853,"title":"Jo\u00e3o Lacerda","filename":"Joao-Lacerda.png","filesize":614703,"url":"https:\/\/gimm.pt\/wp-content\/uploads\/2024\/07\/Joao-Lacerda.png","link":"https:\/\/gimm.pt\/pt-pt\/o-nosso-trabalho\/laboratorios\/laboratorio-maria-mota\/joao-lacerda-2\/","alt":"","author":"1004","description":"","caption":"","name":"joao-lacerda-2","status":"inherit","uploaded_to":1316,"date":"2026-03-13 09:31:00","modified":"2026-03-13 09:31:00","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/gimm.pt\/wp-includes\/images\/media\/default.png","width":600,"height":600,"sizes":{"thumbnail":"https:\/\/gimm.pt\/wp-content\/uploads\/2024\/07\/Joao-Lacerda-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/gimm.pt\/wp-content\/uploads\/2024\/07\/Joao-Lacerda-300x300.png","medium-width":300,"medium-height":300,"medium_large":"https:\/\/gimm.pt\/wp-content\/uploads\/2024\/07\/Joao-Lacerda.png","medium_large-width":600,"medium_large-height":600,"large":"https:\/\/gimm.pt\/wp-content\/uploads\/2024\/07\/Joao-Lacerda.png","large-width":600,"large-height":600,"1536x1536":"https:\/\/gimm.pt\/wp-content\/uploads\/2024\/07\/Joao-Lacerda.png","1536x1536-width":600,"1536x1536-height":600,"2048x2048":"https:\/\/gimm.pt\/wp-content\/uploads\/2024\/07\/Joao-Lacerda.png","2048x2048-width":600,"2048x2048-height":600}}},"_links":{"self":[{"href":"https:\/\/gimm.pt\/pt-pt\/wp-json\/wp\/v2\/lab\/1309"}],"collection":[{"href":"https:\/\/gimm.pt\/pt-pt\/wp-json\/wp\/v2\/lab"}],"about":[{"href":"https:\/\/gimm.pt\/pt-pt\/wp-json\/wp\/v2\/types\/lab"}],"wp:attachment":[{"href":"https:\/\/gimm.pt\/pt-pt\/wp-json\/wp\/v2\/media?parent=1309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}