{"id":1313,"date":"2024-07-31T14:29:45","date_gmt":"2024-07-31T14:29:45","guid":{"rendered":"https:\/\/gimm.pt\/our-work\/laboratories\/laboratorio-leonor-saude\/"},"modified":"2024-12-17T10:10:27","modified_gmt":"2024-12-17T10:10:27","slug":"laboratorio-leonor-saude","status":"publish","type":"lab","link":"https:\/\/gimm.pt\/pt-pt\/o-nosso-trabalho\/laboratorios\/laboratorio-leonor-saude\/","title":{"rendered":"Laborat\u00f3rio Leonor Sa\u00fade"},"content":{"rendered":"\n

Regenera\u00e7\u00e3o da medula espinhal e microambiente tecidular<\/h3>\n\n\n\n

<\/p>\n\n\n\n

As les\u00f5es da medula espinhal nos seres humanos deixam os doentes com incapacidades permanentes devido \u00e0 falta de regenera\u00e7\u00e3o. Em contraste, a medula espinhal do peixe-zebra tem uma capacidade espantosa de recuperar de les\u00f5es, permitindo que estes peixes voltem a nadar. No peixe-zebra, uma les\u00e3o na medula espinhal promove a prolifera\u00e7\u00e3o de c\u00e9lulas estaminais neurais que residem na medula espinhal, e o mesmo \u00e9 provavelmente verdade nos mam\u00edferos. No entanto, o microambiente da medula espinhal dos mam\u00edferos suprime fortemente a regenera\u00e7\u00e3o, enquanto o peixe-zebra a apoia.<\/p>\n\n\n\n

O nosso laborat\u00f3rio est\u00e1 totalmente empenhado em compreender a biologia do microambiente tecidular de uma medula espinhal lesionada num animal em regenera\u00e7\u00e3o (ou seja, o peixe-zebra) e num animal n\u00e3o regenerado (ou seja, o rato).<\/p>\n\n\n\n

Acreditamos que, se criarmos um microambiente permissivo que favore\u00e7a a regenera\u00e7\u00e3o, como o do peixe-zebra, poderemos melhorar consideravelmente as defici\u00eancias motoras e sensitivas que resultam de uma les\u00e3o da medula espinhal nos mam\u00edferos.<\/p>\n\n\n\n

Encontra-nos no Instagram @lsaudelab<\/a><\/p>\n\n\n\n

Neuropal – Jogo online sobre a seguran\u00e7a e o sistema nervoso<\/strong><\/h5>\n\n\n\n

O Neuropal quer ajudar-nos a reconhecer situa\u00e7\u00f5es de risco e a adotar comportamentos seguros que possam prevenir les\u00f5es graves, ao mesmo tempo que explora a anatomia do sistema nervoso e as importantes fun\u00e7\u00f5es que ele desempenha.<\/p>\n\n\n\n

O jogo leva-nos numa aventura com dois amigos, Neuropal e Neuro, de f\u00e9rias num para\u00edso tropical. Eventos inesperados for\u00e7am todos a escapar e Neuropal ter\u00e1 que percorrer diferentes paisagens e desafios para deixar a ilha em seguran\u00e7a. Cada n\u00edvel conclu\u00eddo pode ser repetido quantas vezes quisermos, para mostrar as nossas novas habilidades de seguran\u00e7a e melhorar a nossa pontua\u00e7\u00e3o. O Neuropal tamb\u00e9m inclui quizzes sobre seguran\u00e7a e um gloss\u00e1rio onde podemos explorar mais sobre o sistema nervoso.<\/p>\n\n\n\n

V\u00ea mais aqui<\/a>.<\/strong><\/p>\n","protected":false},"featured_media":0,"template":"","acf":{"header_image":false,"ongoing_projects":"","selected_publications":"","useful_links":"","awards":"","funding":null,"sponsorship":null,"extra_information":false,"location":"Lisboa","subtitle":"Regenera\u00e7\u00e3o da medula espinhal e microambiente tecidular","team_leader":[],"order":"340","related_research_areas":[1500],"lab_members":[{"ID":8347,"post_author":"1004","post_date":"2025-05-27 13:42:51","post_date_gmt":"2025-05-27 13:42:51","post_content":"","post_title":"Leonor Sa\u00fade","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"maria-leonor-tavares-saude","to_ping":"","pinged":"","post_modified":"2026-03-13 10:02:54","post_modified_gmt":"2026-03-13 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