<\/p>\n\n
O laborat\u00f3rio de regula\u00e7\u00e3o do ciclo celular<\/strong> est\u00e1 interessado nos princ\u00edpios gerais da biologia relativos \u00e0 montagem e manuten\u00e7\u00e3o de estruturas subcelulares complexas, bem como nas suas varia\u00e7\u00f5es, que podem ocorrer durante o desenvolvimento, a doen\u00e7a e a evolu\u00e7\u00e3o.<\/p>\n\n Os centr\u00edolos s\u00e3o cilindros baseados em microt\u00fabulos que formam os centrossomas e os c\u00edlios, estruturas envolvidas em muitas fun\u00e7\u00f5es, desde a divis\u00e3o celular at\u00e9 \u00e0 motilidade. Os defeitos dos centrossomas s\u00e3o observados em muitos cancros, enquanto as anomalias nos c\u00edlios conduzem a muitas doen\u00e7as, incluindo rins polic\u00edsticos e infertilidade.<\/p>\n\n Finalmente, os centr\u00edolos e os c\u00edlios s\u00e3o altamente conservados ao longo da \u00e1rvore eucari\u00f3tica da vida, mas perderam-se numa variedade de esp\u00e9cies, sendo um excelente caso de estudo para investigar a evolu\u00e7\u00e3o das estruturas celulares eucari\u00f3ticas.<\/p>\n\n Utilizando abordagens multidisciplinares, o laborat\u00f3rio identificou mecanismos cr\u00edticos que regulam a montagem, manuten\u00e7\u00e3o e fun\u00e7\u00e3o do centr\u00edolo e dos c\u00edlios. Tamb\u00e9m caracterizaram os mecanismos envolvidos na varia\u00e7\u00e3o dessas estruturas durante o desenvolvimento e a evolu\u00e7\u00e3o, e na doen\u00e7a humana.<\/p>\n","protected":false},"featured_media":0,"template":"","acf":{"header_image":false,"ongoing_projects":"","selected_publications":"","useful_links":"","awards":"","funding":null,"sponsorship":null,"extra_information":false,"location":"Oeiras","subtitle":"Regula\u00e7\u00e3o do ciclo celular","team_leader":[],"order":"40","related_research_areas":[1500],"lab_members":[{"ID":8314,"post_author":"1004","post_date":"2025-05-27 13:42:55","post_date_gmt":"2025-05-27 13:42:55","post_content":"","post_title":"M\u00f3nica Bettencourt-Dias","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"monica-bettencourt-carvalho-dias","to_ping":"","pinged":"","post_modified":"2026-03-13 10:00:35","post_modified_gmt":"2026-03-13 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