<\/p>\n\n
As bact\u00e9rias utilizam pequenas mol\u00e9culas qu\u00edmicas chamadas auto-indutores para comunicar umas com as outras atrav\u00e9s de um processo chamado quorum sensing. Este processo permite que uma popula\u00e7\u00e3o de bact\u00e9rias regule os comportamentos, que s\u00f3 s\u00e3o produtivos quando muitas bact\u00e9rias actuam em conjunto como um grupo, \u00e0 semelhan\u00e7a do que acontece com os organismos multicelulares.<\/p>\n\n
Os comportamentos regulados pela dete\u00e7\u00e3o de quorum s\u00e3o frequentemente cruciais para o sucesso das rela\u00e7\u00f5es bact\u00e9ria-hospedeiro, quer sejam simbi\u00f3ticas ou patog\u00e9nicas.<\/p>\n\n
No laborat\u00f3rio de sinaliza\u00e7\u00e3o bacteriana<\/strong> s\u00e3o utilizadas abordagens bioqu\u00edmicas e gen\u00e9ticas para estudar os mecanismos moleculares subjacentes ao quorum sensing, com \u00eanfase nos sistemas que promovem a comunica\u00e7\u00e3o bacteriana entre esp\u00e9cies.<\/p>\n\n Esta investiga\u00e7\u00e3o inclui um estudo integrado que envolve a elucida\u00e7\u00e3o das mol\u00e9culas qu\u00edmicas que s\u00e3o utilizadas como sinais, os componentes da rede envolvidos na dete\u00e7\u00e3o dos sinais e no processamento da informa\u00e7\u00e3o no interior das c\u00e9lulas individuais e, finalmente, a carateriza\u00e7\u00e3o do comportamento da comunidade bacteriana em cons\u00f3rcios bacterianos multiesp\u00e9cies.<\/p>\n\n O objetivo final da investiga\u00e7\u00e3o \u00e9 compreender de que forma a sinaliza\u00e7\u00e3o bacteriana molda as comunidades de microbiota bacteriana multi-esp\u00e9cies que podem ser encontradas em animais e plantas e de que forma estas comunidades afectam a fisiologia do hospedeiro. 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