{"id":7192,"date":"2025-05-27T13:45:56","date_gmt":"2025-05-27T13:45:56","guid":{"rendered":"https:\/\/gimm.pt\/people\/anne-valerie-gendrel\/"},"modified":"2026-05-06T14:59:26","modified_gmt":"2026-05-06T14:59:26","slug":"anne-valerie-gendrel","status":"publish","type":"people","link":"https:\/\/gimm.pt\/pt-pt\/people\/anne-valerie-gendrel\/","title":{"rendered":"Anne-Valerie Gendrel"},"content":{"rendered":"\n<p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.<\/p>\n","protected":false},"featured_media":5965,"template":"","positions":[71],"acf":{"gimm_id":"IMM102309","email":"anne-valerie.gendrel@gimm.pt","tax_position":{"term_id":71,"name":"Researcher","slug":"researcher","term_group":0,"term_taxonomy_id":71,"taxonomy":"positions","description":"","parent":0,"count":39,"filter":"raw"},"group":{"term_id":44,"name":"Discovery","slug":"discovery","term_group":0,"term_taxonomy_id":44,"taxonomy":"infrastructure_group","description":"","parent":0,"count":810,"filter":"raw"},"laboratories":[{"ID":1307,"post_author":"1004","post_date":"2024-07-31 14:29:45","post_date_gmt":"2024-07-31 14:29:45","post_content":"<!-- wp:heading {\"level\":3} -->\n<h3 class=\"wp-block-heading\">Cromatina e Epigen\u00e9tica<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>A nossa investiga\u00e7\u00e3o centra-se nos mecanismos que controlam a din\u00e2mica da cromatina durante a transcri\u00e7\u00e3o e a repara\u00e7\u00e3o de danos no ADN e na forma como estes se coordenam com os processos que salvaguardam a integridade do genoma. Os nossos objectivos gerais s\u00e3o dois: em primeiro lugar, pretendemos investigar os aspectos moleculares das diferentes fases do ciclo de transcri\u00e7\u00e3o, centrando-nos no processamento do pr\u00e9-mRNA e nos eventos de modifica\u00e7\u00e3o da cromatina; al\u00e9m disso, estudamos os mecanismos moleculares que detectam, sinalizam e reparam os danos no ADN. Em paralelo, estamos interessados em explorar de que forma as classes abundantes de elementos transpon\u00edveis contribuem para a fun\u00e7\u00e3o e a estabilidade dos genomas dos mam\u00edferos, recorrendo a abordagens funcionais e bioinform\u00e1ticas.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Para o efeito, utilizamos uma estrat\u00e9gia de investiga\u00e7\u00e3o multidisciplinar que combina ferramentas experimentais e abordagens de \u00e1reas como a biologia celular e molecular, a bioqu\u00edmica, a microscopia de c\u00e9lulas vivas, a sequencia\u00e7\u00e3o de nova gera\u00e7\u00e3o e a bioinform\u00e1tica. Um dos principais objectivos da nossa investiga\u00e7\u00e3o \u00e9 compreender de que forma as altera\u00e7\u00f5es na transcri\u00e7\u00e3o, no processamento do pr\u00e9-mRNA, na modifica\u00e7\u00e3o da cromatina e na resposta aos danos no ADN est\u00e3o ligadas ao desenvolvimento de doen\u00e7as humanas como o cancro.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:gimm\/section {\"name\":\"gimm\/section\",\"data\":{\"show_in_menu\":\"0\",\"_show_in_menu\":\"field_66d0a87f5d400\",\"display_title\":\"0\",\"_display_title\":\"field_66d0a9685d402\",\"display_divider\":\"0\",\"_display_divider\":\"field_282D01283CD\",\"background_animation\":\"0\",\"_background_animation\":\"field_282D0128sd123CD\"},\"mode\":\"preview\"} -->\n<!-- wp:gimm\/partner-list {\"name\":\"gimm\/partner-list\",\"data\":{\"title\":\"Funders\",\"_title\":\"field_66ceaa3bda9f5\",\"partner\":[\"8527\",\"665\",\"2755\",\"3236\"],\"_partner\":\"field_66ceaa08da9f4\",\"display\":\"carousel\",\"_display\":\"field_66ea2saAaAq20a9f9690\"},\"mode\":\"edit\"} \/-->\n<!-- \/wp:gimm\/section -->\n\n<!-- wp:gimm\/section {\"name\":\"gimm\/section\",\"data\":{\"show_in_menu\":\"0\",\"_show_in_menu\":\"field_66d0a87f5d400\",\"display_title\":\"0\",\"_display_title\":\"field_66d0a9685d402\",\"display_divider\":\"1\",\"_display_divider\":\"field_282D01283CD\",\"background_animation\":\"0\",\"_background_animation\":\"field_282D0128sd123CD\"},\"mode\":\"preview\"} -->\n<!-- wp:gimm\/accordion {\"name\":\"gimm\/accordion\",\"data\":{\"accordion_0_title\":\"\u00c1reas de Investiga\u00e7\u00e3o\",\"_accordion_0_title\":\"field_66ce5c73ac8d9\",\"accordion_0_content\":\"\\u003ch2\\u003eResposta ao Dano no DNA e Repara\u00e7\u00e3o\\u003c\/h2\\u003e\\r\\n\\u003cp style=\\u0022font-weight: 400;\\u0022\\u003eInvestigamos os mecanismos celulares que detetam, sinalizam e reparam o dano no DNA para manter a estabilidade do genoma. O nosso foco inclui as vias de repara\u00e7\u00e3o de roturas de cadeia dupla do DNA, como a recombina\u00e7\u00e3o hom\u00f3loga e a jun\u00e7\u00e3o de extremidades n\u00e3o hom\u00f3logas. Exploramos o papel da estrutura e din\u00e2mica da cromatina na coordena\u00e7\u00e3o do processo de repara\u00e7\u00e3o e o seu envolvimento na preven\u00e7\u00e3o da instabilidade gen\u00f3mica.\\u003c\/p\\u003e\\r\\n\\u0026nbsp;\\r\\n\\u003ch2\\u003eR-loops e Instabilidade Gen\u00f3mica Associada \u00e0 Transcri\u00e7\u00e3o\\u003c\/h2\\u003e\\r\\n\\u003cp style=\\u0022font-weight: 400;\\u0022\\u003eEstudamos como os R-loops, estruturas h\u00edbridas de RNA-DNA que se formam durante a transcri\u00e7\u00e3o, contribuem para a instabilidade gen\u00f3mica. A nossa investiga\u00e7\u00e3o centra-se na compreens\u00e3o dos mecanismos envolvidos na regula\u00e7\u00e3o dos R-loops e na forma como a sua desregula\u00e7\u00e3o conduz a danos no DNA associados \u00e0 transcri\u00e7\u00e3o. Pretendemos descobrir as vias moleculares que as c\u00e9lulas utilizam para resolver a instabilidade gen\u00f3mica induzida por R-loops.\\u003c\/p\\u003e\\r\\n\\u0026nbsp;\\r\\n\\u003ch2\\u003eRegula\u00e7\u00e3o da Transcri\u00e7\u00e3o e Processamento do Pr\u00e9-mRNA\\u003c\/h2\\u003e\\r\\n\\u003cp style=\\u0022font-weight: 400;\\u0022\\u003eExploramos como o ciclo de transcri\u00e7\u00e3o est\u00e1 estreitamente acoplado a eventos de processamento do pr\u00e9-mRNA, como o splicing. Atrav\u00e9s do estudo de mecanismos regulat\u00f3rios chave do splicing, pretendemos compreender de que forma os defeitos na transcri\u00e7\u00e3o e no processamento do mRNA contribuem para o stress transcricional e a instabilidade gen\u00f3mica.\\u003c\/p\\u003e\\r\\n\\u0026nbsp;\\r\\n\\u003ch2\\u003eInstabilidade Gen\u00f3mica no Cancro\\u003c\/h2\\u003e\\r\\n\\u003cp style=\\u0022font-weight: 400;\\u0022\\u003eInvestigamos como a instabilidade gen\u00f3mica impulsiona a progress\u00e3o do cancro, com foco em muta\u00e7\u00f5es em genes de repara\u00e7\u00e3o do DNA e reguladores da cromatina. O nosso trabalho visa revelar como os defeitos na resposta ao dano no DNA, aliados ao stress de transcri\u00e7\u00e3o e replica\u00e7\u00e3o, contribuem para a tumorig\u00e9nese. Adicionalmente, exploramos o potencial de direcionar terapias anticancer\u00edgenas para a instabilidade gen\u00f3mica, explorando vulnerabilidades nas vias de repara\u00e7\u00e3o do DNA das c\u00e9lulas cancerosas.\\u003c\/p\\u003e\\r\\n\\u0026nbsp;\\r\\n\\u003ch2\\u003eElementos Transpon\u00edveis e Fun\u00e7\u00e3o do Genoma\\u003c\/h2\\u003e\\r\\n\\u003cp style=\\u0022font-weight: 400;\\u0022\\u003ePretendemos compreender como os elementos transpon\u00edveis, em particular os da fam\u00edlia LINE-1, evolu\u00edram para regular o desenvolvimento dos mam\u00edferos e como a sua desregula\u00e7\u00e3o pode contribuir para o envelhecimento e para o estabelecimento e progress\u00e3o de contextos patol\u00f3gicos, em particular perturba\u00e7\u00f5es neurol\u00f3gicas como o s\u00edndrome de Rett. Para tal, combinamos modelos de c\u00e9lulas estaminais e seus derivados diferenciados com abordagens baseadas em CRISPR-Cas9 e tecnologias de sequencia\u00e7\u00e3o de nova gera\u00e7\u00e3o.\\u003c\/p\\u003e\",\"_accordion_0_content\":\"field_66ce5c85ac8da\",\"accordion_1_title\":\"Projetos\",\"_accordion_1_title\":\"field_66ce5c73ac8d9\",\"accordion_1_content\":\"\\u003cstrong\\u003e2025-2027:\\u003c\/strong\\u003e Unveiling the DNA Damage Response in Skeletal Muscle Resilience and Repair. Coordena\u00e7\u00e3o: S\u00e9rgio de Almeida. Ag\u00eancia Financiadora: AFM-Telethon.\\r\\n\\r\\n\\u003cstrong\\u003e2025-2026:\\u003c\/strong\\u003e AIR-LOOP - Innovative strategies for targeting hidden weaknesses in cancer cells. Cordena\u00e7\u00e3o: Robert Martin \\u0026amp; S\u00e9rgio de Almeida. Funding Agency: \\u0022la Caixa\\u0022 Foundation - Impulse Health Innovation.\\r\\n\\r\\n\\u003cstrong\\u003e2025-2027:\\u003c\/strong\\u003e CRISPR-based genome-wide screens for new regulators of LINE-1 elements activity. Coordena\u00e7\u00e3o: Anne-Valerie Gendrel. Funding Agency: Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia.\\r\\n\\r\\n\\u003cstrong\\u003e2024-2027:\\u003c\/strong\\u003e BIOMICS: Fostering Excellent Research, Training and Innovation in Biomedical Data Science. Parceiros: S\u00e9rgio de Almeida \\u0026amp; Anne-Valerie Gendrel. Ag\u00eancia Financiadora: EU twinning initiative (Horizon Europe).\\r\\n\\r\\n\\u003cstrong\\u003e2024:\\u003c\/strong\\u003e TessellateBio. Coordena\u00e7\u00e3o: S\u00e9rgio de Almeida. Ag\u00eancia Financiadora: Tessellate Bio BV.\",\"_accordion_1_content\":\"field_66ce5c85ac8da\",\"accordion_2_title\":\"Projetos Anteriores\",\"_accordion_2_title\":\"field_66ce5c73ac8d9\",\"accordion_2_content\":\"\\u003cstrong\\u003e2023-2024:\\u003c\/strong\\u003e New horizons for Rett syndrome: exploring the role of transposable elements using genetically engineered human stem cell models. Coordena\u00e7\u00e3o: Anne-Valerie Gendrel. Ag\u00eancia Financiadora: Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia.\\r\\n\\r\\n\\u003cstrong\\u003e2023-2024:\\u003c\/strong\\u003e Investigating R-loops as important regulators of splicing. Coordena\u00e7\u00e3o: Robert Manfred Martin. Ag\u00eancia Financiadora: Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia.\\r\\n\\r\\n\\u003cstrong\\u003e2021-2024:\\u003c\/strong\\u003e O Papel da Transcri\u00e7\u00e3o Induzida por Quebras do DNA no Envelhecimento\u00a0\u00a0 - Decoding the Role of DNA Break-Induced Transcription in Ageing. Coordena\u00e7\u00e3o: S\u00e9rgio de Almeida. Ag\u00eancia Financiadora: Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia.\\r\\n\\r\\n\\u003cstrong\\u003e2021-2023:\\u003c\/strong\\u003e Exploring the contribution of transposable elements for the pathogenesis of Rett syndrome. Coordena\u00e7\u00e3o: Anne-Valerie Gendrel. Ag\u00eancia Financiadora: International Rett Syndrome Foundation.\\r\\n\\r\\n\\u003cstrong\\u003e2019-2022:\\u003c\/strong\\u003e Ribomed: RNA in Disease. Parceiro: S\u00e9rgio de Almeida. Ag\u00eancia Financiadora: EU twinning initiative (Horizon 2020).\",\"_accordion_2_content\":\"field_66ce5c85ac8da\",\"accordion_3_title\":\"Publica\u00e7\u00f5es Selecionadas\",\"_accordion_3_title\":\"field_66ce5c73ac8d9\",\"accordion_3_content\":\"Gendrel, A.-V. (2025). The LINE\u20101 paradox: Active yet immobile. BioEssays, 47(2):e2400256. \\u003ca href=\\u0022https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.202400256\\u0022\\u003ehttps:\/\/doi\/10.1002\/bies.202400256\\u003c\/a\\u003e.\\r\\n\\r\\nLe Breton, A., Bettencourt, M. P., and Gendrel, A.-V. (2024) Navigating the brain and aging: exploring the impact of transposable elements from health to disease. Front Cell Dev Biol, 12:1357576. https:\/\/\\u003ca href=\\u0022https:\/\/www.frontiersin.org\/journals\/cell-and-developmental-biology\/articles\/10.3389\/fcell.2024.1357576\/full\\u0022\\u003edoi\/10.3389\/fcell.2024.1357576\\u003c\/a\\u003e.\\r\\n\\u003cp data-start=\\u00220\\u0022 data-end=\\u0022230\\u0022\\u003eR.M. Martin, M.R. de Almeida, E. Gameiro, S.F. de Almeida (2023). Live-cell imaging unveils distinct R-loop populations with heterogeneous dynamics. \\u003cem data-start=\\u0022149\\u0022 data-end=\\u0022173\\u0022\\u003eNucleic Acids Research\\u003c\/em\\u003e, Oct 11: gkad812. \\u003ca href=\\u0022https:\/\/doi.org\/10.1093\/nar\/gkad812\\u0022 target=\\u0022_new\\u0022 rel=\\u0022noopener\\u0022 data-start=\\u0022192\\u0022 data-end=\\u0022227\\u0022\\u003ehttps:\/\/doi.org\/10.1093\/nar\/gkad812\\u003c\/a\\u003e.\\u003c\/p\\u003e\\r\\n\\u003cp data-start=\\u0022232\\u0022 data-end=\\u0022503\\u0022\\u003eJ.C. Sabino, M.R. de Almeida, P.L. Abreu, A.M. Ferreira, M.M. Domingues, N.C. Santos, C.M. Azzalin, A.R. Grosso, S.F. de Almeida (2022). Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops. \\u003cem data-start=\\u0022445\\u0022 data-end=\\u0022452\\u0022\\u003eeLife\\u003c\/em\\u003e 11: e69476. \\u003ca href=\\u0022https:\/\/doi.org\/10.7554\/eLife.69476\\u0022 target=\\u0022_new\\u0022 rel=\\u0022noopener\\u0022 data-start=\\u0022465\\u0022 data-end=\\u0022500\\u0022\\u003ehttps:\/\/doi.org\/10.7554\/eLife.69476\\u003c\/a\\u003e.\\u003c\/p\\u003e\\r\\n\\u003cp data-start=\\u0022505\\u0022 data-end=\\u0022701\\u0022\\u003eE.R. Gomes, S.F. de Almeida (2021). TREX1-dependent DNA damage links nuclear rupture to tumor cell invasion. \\u003cem data-start=\\u0022614\\u0022 data-end=\\u0022634\\u0022\\u003eDevelopmental Cell\\u003c\/em\\u003e 56(22): 3040-3041. \\u003ca href=\\u0022https:\/\/doi.org\/10.1016\/j.devcel.2021.11.003\\u0022\\u003ehttps:\/\/doi.org\/10.1016\/j.devcel.2021.11.003\\u003c\/a\\u003e.\\u003c\/p\\u003e\\r\\n\\u003cp data-start=\\u0022703\\u0022 data-end=\\u0022945\\u0022\\u003eA.C. V\u00edtor, S.C. Sridhara, J.C. Sabino, A.I. Afonso, A.R. Grosso, R.M. Martin, S.F. de Almeida (2019). Single-molecule imaging of transcription at damaged chromatin. \\u003cem data-start=\\u0022869\\u0022 data-end=\\u0022887\\u0022\\u003eScience Advances\\u003c\/em\\u003e 5(1): eaau1249. \\u003ca href=\\u0022https:\/\/doi.org\/10.1126\/sciadv.aau1249\\u0022 target=\\u0022_new\\u0022 rel=\\u0022noopener\\u0022 data-start=\\u0022904\\u0022 data-end=\\u0022942\\u0022\\u003ehttps:\/\/doi.org\/10.1126\/sciadv.aau1249\\u003c\/a\\u003e.\\u003c\/p\\u003e\\r\\n\\u003cp data-start=\\u0022947\\u0022 data-end=\\u00221223\\u0022\\u003eS.C. Sridhara, S. Carvalho, A.R. Grosso, L.M. Gallego-Paez, M. Carmo-Fonseca, S.F. de Almeida (2017). Transcription dynamics prevent RNA-mediated genomic instability through SRPK2-dependent DDX23 phosphorylation. \\u003cem data-start=\\u00221160\\u0022 data-end=\\u00221174\\u0022\\u003eCell Reports\\u003c\/em\\u003e. \\u003ca href=\\u0022https:\/\/doi.org\/10.1016\/j.celrep.2016.12.050\\u0022 target=\\u0022_new\\u0022 rel=\\u0022noopener\\u0022 data-start=\\u00221176\\u0022 data-end=\\u00221220\\u0022\\u003ehttps:\/\/doi.org\/10.1016\/j.celrep.2016.12.050\\u003c\/a\\u003e.\\u003c\/p\\u003e\\r\\n\\u003cp data-start=\\u00221225\\u0022 data-end=\\u00221531\\u0022\\u003eA.R. Grosso, A.P. Leite, S. Carvalho, M.R. Matos, F.B. Martins, A.C. V\u00edtor, J.M. Desterro, M. Carmo-Fonseca, S.F. de Almeida (2015). Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma. \\u003cem data-start=\\u00221474\\u0022 data-end=\\u00221481\\u0022\\u003eeLife\\u003c\/em\\u003e 4: e09214. \\u003ca href=\\u0022https:\/\/doi.org\/10.7554\/eLife.09214\\u0022 target=\\u0022_new\\u0022 rel=\\u0022noopener\\u0022 data-start=\\u00221493\\u0022 data-end=\\u00221528\\u0022\\u003ehttps:\/\/doi.org\/10.7554\/eLife.09214\\u003c\/a\\u003e.\\u003c\/p\\u003e\",\"_accordion_3_content\":\"field_66ce5c85ac8da\",\"accordion_4_title\":\"Pr\u00e9mios\",\"_accordion_4_title\":\"field_66ce5c73ac8d9\",\"accordion_4_content\":\"\\u003cp style=\\u0022font-weight: 400;\\u0022\\u003e\\u003cstrong\\u003e2015:\\u003c\/strong\\u003ePr\u00e9mio da Sociedade Portuguesa de Gen\u00e9tica Humana\\u003c\/p\\u003e\\r\\n\\u003cp style=\\u0022font-weight: 400;\\u0022\\u003e\\u003cstrong\\u003e2011:\\u003c\/strong\\u003e Pr\u00e9mio Pfizer Award de Investiga\u00e7\u00e3o B\u00e1sica\\u003c\/p\\u003e\\r\\n\\u003cp style=\\u0022font-weight: 400;\\u0022\\u003e\\u003cstrong\\u003e2006:\\u003c\/strong\\u003e Pr\u00e9mio LabMed Science\\u003c\/p\\u003e\",\"_accordion_4_content\":\"field_66ce5c85ac8da\",\"accordion\":5,\"_accordion\":\"field_66ce5c1fac8d8\"},\"mode\":\"edit\"} \/-->\n<!-- \/wp:gimm\/section -->","post_title":"Laborat\u00f3rio S\u00e9rgio de Almeida","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"laboratorio-sergio-de-almeida","to_ping":"","pinged":"","post_modified":"2026-05-11 08:47:16","post_modified_gmt":"2026-05-11 08:47:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/gimm.pt\/our-work\/laboratories\/laboratorio-sergio-de-almeida\/","menu_order":0,"post_type":"lab","post_mime_type":"","comment_count":"0","filter":"raw"}],"order":"0","location":"oeiras","phone_extension":"","infrastructure":""},"_links":{"self":[{"href":"https:\/\/gimm.pt\/pt-pt\/wp-json\/wp\/v2\/people\/7192"}],"collection":[{"href":"https:\/\/gimm.pt\/pt-pt\/wp-json\/wp\/v2\/people"}],"about":[{"href":"https:\/\/gimm.pt\/pt-pt\/wp-json\/wp\/v2\/types\/people"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gimm.pt\/pt-pt\/wp-json\/wp\/v2\/media\/5965"}],"wp:attachment":[{"href":"https:\/\/gimm.pt\/pt-pt\/wp-json\/wp\/v2\/media?parent=7192"}],"wp:term":[{"taxonomy":"positions","embeddable":true,"href":"https:\/\/gimm.pt\/pt-pt\/wp-json\/wp\/v2\/positions?post=7192"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}