Cell Architecture

Connecting the nucleus to the cytoskeleton is relevant for multiple cellular processes, and disruption of these connections result in various pathologies. Nuclear positioning within the cell cytoplasm requires the connection between the nucleus and the cytoskeleton.

We are interested in understanding the processes involved in these connections and the role of nuclear positioning in cell function. We are studying cell migration and skeletal myofiber formation, which require the connection between the nucleus and the cytoskeleton, as well as precise nuclear positioning. We use different molecular and cellular approaches in combination with time-lapse imaging analysis to address these questions.