Marc Veldhoen Lab

Immune regulation

Epithelial barrier sites such as the skin, respiratory and gastrointestinal tract, form a physical interface between our bodies and external environments. In addition to creating a physical impediment to pathogens, epithelial barriers include a diverse mix of immune cells, forming a first line of defence against invading pathogens.

Our laboratory studies the role that cells of the immune system play at the initiation, modulation and resolution of immune responses at epithelial barrier sites as well as the homeostatic control of epithelial cells. These studies provide insights into the mechanisms that control the maintenance, activation and function of immune cells located or enriched at mucosal surfaces such as the intestine, ultimately contributing to the prevention of undesirable immune responses that may result in chronic infections, allergies, autoimmunity and an increased risk of cancer.

Marc Veldhoen | Era Chair Holder – This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 667824.