The Metabolomics Unit will use a range of mass spectrometry technologies to support metabolism research and biomarker analysis. We will use gas and liquid chromatography mass spectrometry approaches to perform both discovery- and hypothesis-driven metabolomics analysis. We also aim to support stable isotope tracing studies and to develop a lipidomics platform to provide insights into lipid metabolism.
Besides providing multiple services for the measurement of metabolites using the latest technologies and methodology, we will assist users in each step of the process – from experimental design for metabolomics, to sample preparation, data analysis and interpretation of results. Our goal is to help researchers answer their metabolism questions and to be able to provide meaningful scientific contributions.
The Metabolomics Unit will be located in Oeiras and we expect to have it running early in 2025. Until then, we are available to provide consultation services in experimental design, data analysis and data interpretation.
Contact:
Sara Violante, Head of Metabolomics
sara.violante@gimm.pt
Consultation Services: The facility will assist users in experimental design for metabolomics, data analysis and data interpretation.
Untargeted metabolomics/lipidomics analysis, including:
· Polar metabolite profiling
· Non-polar and lipidomics profiling
· Molecular networking analysis and metabolite identification
Targeted panels
· Neuroactive molecules
· Polyamines
· Fatty acid and acylcarnitines
· Complex lipids
Stable isotope tracing studies
Biomarker quantification
This service is provided upon request.
Courses and workshops
The facility will be equipped with state-of-the-art gas and liquid chromatography mass spectrometers:
GC-MS: Thermo iSQ7610 VPICI
LC-MS/MS quadrupole with linear trap: Thermo Stellar MS
LC-MS/MS High resolution Orbitrap: Thermo Exploris 240 MS
The services of the Metabolomics Unit are available to GIMM researchers and external users.
All users interested in using the services from the facility, please contact Sara Violante (sara.violante@gimm.pt) for more information and to schedule a meeting to discuss the projects.